# Matthew Corley > Senior Software Engineer, Research Platform at Freenome Location: San Francisco Bay Area, United States Profile: https://flows.cv/matthewcorley I am a software engineer with a focus on data and distributed systems. I enjoy working on projects that allow me to leverage my background in the natural sciences, which includes extensive experience conducting basic research in the life sciences (developmental genetics, genomics, and computational biology). ## Work Experience ### Senior Software Engineer @ Freenome Jan 2023 – Present | San Francisco Bay Area ### Senior Software Engineer, Health Machine Learning @ 23andMe Jan 2020 – Jan 2022 ### Software Engineer - Big Data Platform @ 23andMe Jan 2019 – Jan 2020 | Sunnyvale, CA ### Software Engineer @ Synthego Corporation Jan 2018 – Jan 2019 | San Francisco Bay Area Synthego's mission is to turn biology into an information science by enabling automated genome engineering at scale. As a software engineer, I collaborated with engineers and scientists across the organization to deliver systems that improved the quality, efficiency and automation of our production laboratories. Some examples of projects I lead: • Design and implementation of core microservices using Python and gRPC, e.g. a real-time notication service guaranteeing at least-once, in-order delivery of asynchronous events to third party APIs. • Migrating the core Django monolith, responsible for coordinating all activity in our robotic laboratories, from our on premises data center to the cloud (AWS EC2 and RDS). • Hardening operation of our backend services, including: automated provisioning and deployment, centralized logging, instrumentation (metrics, distributed tracing), and real-time monitoring and alerting. ### Software Engineer @ SignalFx Jan 2016 – Jan 2018 | San Francisco Bay Area SignalFx is a highly available, streaming time series processing engine that ingests, stores, and analyzes billions of datapoints per day with end-to-end latency of a few seconds. Some of my contributions included: - Owning development and operation of the Kafka-based message bus supporting streaming data pipelines - Design and implementation of public-facing RESTful APIs for features like attribute-based access control and streaming dashboards and data visualizations. - leading development of a new distributed tracing product ### Graduate Researcher, Human Cancer Genomics/Regenerative Medicine @ Washington University School of Medicine Jan 2012 – Jan 2015 • developed improved computational/statistical methods for the analysis and interpretation of next gen sequencing experiments (Python/Cython, SQLite; gaussian mixture models, negative bionomial regression) • petabyte-­scale data mining, including the analysis of genomes from The Cancer Genome Atlas (TCGA) for 3,000+ patients across eight cancer types (Perl, R, Python) • integrated analysis and visualization of epigenomic data using Python (numpy, scikitlearn, and matplotlib) ### Helpdesk Technology Consultant Coordinator @ Grinnell College Jan 2009 – Jan 2012 | Grinnell, Iowa • Managed a team of approximately 60 employees, including hiring, training and certification, scheduling, and payroll assistance. • Resolved escalated service issues, requiring a detailed knowledge of Windows 7, OS X, and Linux distributions, computer networking, and intermediate hardware repair. • Assisted with programming (PHP, SQL) and maintenance of an in-house employee management database and web portal. ### Undergraduate Researcher, Mentored Advanced Research Project @ Grinnell College Jan 2011 – Jan 2012 | Grinnell College SUPERVISOR: Dr. Vida Praitis PROJECT SUMMARY: Forward genetic screens to dissect the molecular pathway by which the Golgi-linked Ca(2+) ATPase pmr-1 regulates cell migration and tissue organization during C. elegans gastrulation ### Helpdesk Technology Consultant, Information Technology Services @ Grinnell College Jan 2008 – Jan 2009 Multi­platform (Linux, Windows XP/Windows 7, Mac OSX) technical support on­site and by phone for over 1,600 students, faculty, and staff. Provided support for networking, hardware diagnostics/repair, data recovery, A/V setup and configuration, and system administration of academic computing resources (Linux-­based servers and LAN for Math & CS). ### NSF Summer Undergraduate Researcher @ Department of Biology, University of Iowa Jan 2011 – Jan 2011 SUPERVISOR: Dr. Sarit Smolikove PROJECT SUMMARY: A Yeast-2-Hybrid Screen to Identify Novel Protein-Protein Interactions Regulating Disassembly of the Synaptonemal Complex in C. elegans meiosis; Protein Structure Prediction via Homology Modelling ### Summer Undergraduate Researcher @ Carver Center for Genomics, University of Iowa Jan 2010 – Jan 2010 SUPERVISOR: Dr. John Logsdon PROJECT SUMMARY: Comparative genomic analysis of meiotic protein evolution in putative ”ancient asexual” rotifer species; molecular phylogenetic tree construction using Bayesian inference ## Education ### Master of Science - MS in Genome Sciences/Genomics Washington University School of Medicine in St. Louis ### Bachelor of Arts (B.A.) in Biology Grinnell College ### International Affiliate Student in Computational and Systems Biology UCL ## Contact & Social - LinkedIn: https://linkedin.com/in/corleyma --- Source: https://flows.cv/matthewcorley JSON Resume: https://flows.cv/matthewcorley/resume.json Last updated: 2026-03-31