• Developed adaptive projection acquisition approaches for 3D EPR imaging of free radicals; Adapted accordingly the filtered back-projection algorithm for image reconstruction
• Developed and implemented a fast continuous wave (CW) EPR imaging system using spinning/spiral magnetic field gradients enabling an increase of image acquisition speed by an order of magnitude as compared to the conventional methods
• Developed a client/server software using C++ for real-time calculating dynamic nuclear polarization (DNP) spectra based on a commercial NMR console
• Developed a Windows based 4-D spectral-spatial EPR imaging software (Visual C++/MFC source codes>30,000 lines) including hardware control, data acquisition, image reconstruction and post-processing
• Research results from adaptive projection acquisition and fast CW EPR imaging system development led to funding of an NIH research projects program (R01) “Novel Methods for in Vivo Imaging of Tissue Oxygenation”- Principal Investigator: P Kuppusamy (20% effort) and Co-Investigators: Y Deng (50% effort) and J Zweier (5% effort); A total amount of funding $800,000 for 4 years